CARCINOGEN-INDUCED TUMORS OF THE THYMUS

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Carcinogen-induced Tumors of the Thymus

A progressive decrease of the restoring effectivity of syngeneic or allogeneic thymus and functional thymoma grafts was observed when the treatment of neonatally thymectomized mice was delayed. Early treatment (5-20 days postthymectomy) was effective, while the number of restored animals was markedly decreased after late treatment (30-50 days postthymectomy). Similar results were obtained with ...

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Previous studies have shown that intestinal tumors from Apc(Min)(/+) (Min) mice and familial adenomatous polyposis (FAP) patients are often polyclonal. We sought to determine whether polyclonality is unique to tumors arising from hereditary predispositions or, instead, is a common feature of intestinal tumorigenesis in other pathways to tumorigenesis. Ethylnitrosourea-induced intestinal tumors ...

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Carcinoid tumors of the thymus.

Carcinoid tumors arising in the thymus are rare. Since Rosai and Higa in 1972 distinguished these neoplasms from thymomas, fewer than 100 cases have been reported in the world literature. In a 38-year review (1950 to 1988) of surgically treated thymic tumors at Henry Ford Hospital, only 7 cases of thymic carcinoids were identified. These 6 men and 1 woman ranged in age from 27 to 70 years (mean...

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Carcinoid tumors of the thymus.

This paper reports two relatively rare cases of primary carcinoid tumors of the thymus experienced by the authors. One case is a 43-year old male who presented the Zollinger-Ellison (ZE) syndrome and received total gastrectomy and distal pancreatectomy. Mediastinal tumor was found one year and seven months post operatively, for which total extirpation was performed followed by irradiation. The ...

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Ataxia-telangiectasia (A-T), which is due to mutations in the ATM gene, is a rare autosomal recessive genomic instability syndrome characterized by radiosensitivity and predisposition to cancer. Epidemiological studies have suggested that relatives of A-T patients (A-T carriers) have increased risks of developing breast cancer. We propose that increased breast cancer risks in A-T carriers may b...

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ژورنال

عنوان ژورنال: Journal of Experimental Medicine

سال: 1969

ISSN: 1540-9538,0022-1007

DOI: 10.1084/jem.130.4.809